Experimental Framework Abstract The following text outlines a possible experimental structure for the Closing the Loop series. Drawing upon the ideas of Maturana and Varela's autopoietic units, elementary systems theory and the ideas of autocatalysis in general, the framework presented here may contain the right ideas to frame various series of experiments. In connecting these ideas, we come to a framework that guides exploration, leading us to some of the more interesting questions and hopefully allowing us to determine which parts of the answers are in fact interesting. The following text surfs over various ideas from systems theory, whether of the biological, electromechanical or social, and collects the ideas of a calculus of variations. We start with the biomechanical unit, which we take to be our elementary unit of interest. Looking at the way in which this unit relates and refers to other units, biomechanical and other, we develop an idea of a calculus of variations on the flows into and out of this unit. From here we begin to frame some questions relating to the analysis of these flows and theit interrelations. In the unadulterated state, the biomechanical unit is an object experiencing perceptual influences that act upon certain interfaces, causing variations in the system. This system reacts at many levels, as many as there are levels to the biomechanical system. In particular we are interested in the autosomatic aspect, the automatisms, the responses of the biomechanical unit outside of some kind of conscious "control". Closing the loop of autosomatic physiological data to perceptual permutations using various models will allow the analysis of various biomechanical constraints and capabilities.